9/25/2023 0 Comments Microsoft office 2016link itech![]() 4.0%) (relative risk 0.31 95% CI, 0.09–1.11 P = 0.09), but this difference was not statistically significant. 17 The ivermectin arm had a lower risk of mortality than the standard of care arm (1.2% vs. 17.3%) for the primary outcome of risk of progression to severe COVID-19. I-TECH, an open-label trial conducted in Malaysia, found no difference between the ivermectin and standard of care arms (21.6% vs. In the 600 μg/kg phase of the study, the median time to sustained recovery was 11 days for both arms. ![]() ![]() In the 400 μg/kg phase of the study, the median time to sustained recovery was 12 days for the ivermectin arm and 13 days for the placebo arm. 15,16 Participants were randomized to an ivermectin regimen (either 400 μg/kg for 3 days or 600 μg/kg for 6 days) or a matching placebo. The ACTIV-6 trial was an adaptive platform trial conducted in outpatients with mild to moderate COVID-19 in the United States. 4.1%) did not reduce occurrences of a composite outcome of emergency department visits, hospitalization, or death. In COVID-OUT, a randomized factorial trial, the use of ivermectin when compared with a matched control (5.7% vs. 14 In addition, there was no statistically significant difference between the ivermectin and placebo arms in mortality (3.1% vs. In TOGETHER, an adaptive platform trial conducted in Brazil, there was no apparent difference between the ivermectin and placebo arms for the primary outcome of risk of emergency department visits or hospitalization (14.7% vs. Trials have failed to find a clinical benefit from the use of ivermectin for the treatment of COVID-19 in outpatients. ![]() Studies that randomized participants to ivermectin or a matched placebo had the greatest impact on the Panel’s recommendation. The Panel’s recommendation is primarily informed by adequately powered, randomized trials of ivermectin that reported clinical outcomes.
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